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These fluorescently labeled MSVs could be effectively internalized by both a human (BxPC-3) and a mouse pancreatic cancer cell lines (Pan02).
These responsive NPs could be effectively internalized by rat vascular smooth muscle cells, which in turn notably potentiated anti-proliferation and anti-migration activities of RAP.
Moreover, this system can be effectively internalized by tumor cells; it demonstrates a superior cytotoxic activity and a longer incubation time results in higher efficiency.
Since Tat peptide-labeled nanoparticles can be effectively internalized by hematopoietic stem cells and neural progenitor cells, they can localize to hematopoietic and neural tissues and cells.
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Fluorescently labeled ETYIKPWWVWL was effectively internalized by all three variants with EC50 of ∼25 nM.
All combinations were effectively internalized by the cells, with slightly better performance when targeting receptors of different endocytic pathways.
BGNSs@pDA-FA was effectively internalized by cancer cells through folate receptor-mediated endocytosis and generated CO2 bubbles under the acidic environment of the lysosomes, thus enhancing lysosomal membrane permeability (LMP) to release caspase-3 into the cytoplasm, resulting in cancer cell death via an apoptosis-like pathway.
After this period of incubation, images were captured using laser confocal microscopy for the purpose of visualizing the internalization of the developed surface-biofunctionalized ZnS and Zn0.50Cd0.50S QDs. Figure 9B shows that the Zn0.50Cd0.50S (A) and ZnS (B) conjugates were effectively internalized by HEK293T cells.
The siRNA/C8A complexes were effectively internalized by cells and suppressed VEGF mRNA levels by about 65%.
AFM imaging revealed that smaller liposome's (<200 nm) were effectively internalized by cells compared to larger preparations (17).
Staining with Prussian blue confirmed that the nanocarrier could be effectively internalized into HeLa cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com