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On the other hand, mechanisms other than gene mutation could also be effective to alter gene activity.
A non-covalent peptide-based strategy was used for efficient delivery of miR-122 mimic or inhibitor, which appeared to be effective to alter cholesterol levels without cytotoxicity.
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In this respect, various nanosurfaces of intracellular ultrastructures such as cytoskeletons could be also effective to alter the preformed species.
Artificial selection has proven to be effective at altering the performance of animal production systems.
However, since hosts vary widely in susceptibility and tolerance to infection, host-directed therapies are likely to be effective, by altering the biology of a susceptible host to induce a response more similar to a host who survives.
Since education intervention has long been shown to be effective in altering clinicians' behavior [ 23], the integration of up-to-date, evidence-based guidelines into the curricula is important to ensure sustainability in practice.
Owing to its limited statistical power, this study does not alter the conclusions from earlier trials that NSAIDs do not appear to be effective in altering the progression of symptoms in AD.
First, we only tested one single dosage that has been shown to be effective in altering blood glucose levels in rats [ 11, 13].
A systematic review by Kay et al. (1998) has concluded that the various oral health promotion measures have not shown to be effective in altering the behavior and clinic indices of disease.
Early in ARDS, postural changes including CLR and prone positioning can be effective in altering the distribution of ventilation and blood flow [ 13, 14, 15].
Selection can be effective in altering gene frequencies if there is a strong correlation between the phenotype and the genotype, and more so if the character is affected by a small number of genes (Falconer and MacKay 1996).
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