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8 19 20 Primary care referrals to commercial weight loss programmes have been found to be effective in trials.
Successful retention strategies used in other study designs may be effective in trials settings and should be tested.
It has proven to be effective in trials [ 7, 8], and is under the concept of 'tight control' also adopted in the recommendations for daily practice [ 9, 10].
(Clinician/researcher, South Africa) Because practice prior to the landmark trials was often based on MgSO4, many obstetricians noted that they had experienced the clinical success of the drug long before it was shown to be effective in trials: "...even in the absence of a randomised study, I think the empirical results were very convincing".
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Even interventions shown to be effective in clinical trials may not produce the predicted effects in the "real world"—for example, results may be distorted by publication bias or not be applicable beyond the population included in the trial.
In clinical practice, the TI is the range of doses at which a medication appeared to be effective in clinical trials for a median of participants without unacceptable adverse effects.
And it's hard to understand why NHS doctors – who often prescribe generic, off-patent drugs – wouldn't use cheap treatments if they'd been shown to be effective in clinical trials.
In the case of MPS, the compensation of fast-cycled mood disturbances (ultracycling) is achieved by the administration of antiepileptic drugs (i.e., valproate or carbamazepine), which have been found to be effective in clinical trials.
In this context, molecular modeling was used to contrast the properties of the AETP moiety to those of the RGD targeting peptide, already found to be effective in previous trials.
During the last two decades, several immunomodulatory agents and one immunosuppressant drug have been shown to be effective in clinical trials and have been approved on this basis for the treatment of multiple sclerosis.
In addition, RNase A has been confirmed to be able to inhibit the growth of cancer cells as a result of its enzymatic activity of degrading cellular RNA and has been proven to be effective in clinical trials as a chemotherapeutic agent [28, 29].
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CEO of Professional Science Editing for Scientists @ prosciediting.com