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Indeed, chemical chaperones and antioxidants aiming to reduce ER stress and UPR activation have been shown to be effective in mouse models of obesity and type-1 diabetes [3] [5].
111 It remains to be determined, however, whether such curcumin-encapsulated nanoparticles would be effective in mouse models with experimental and/or spontaneous metastases.
Although not yet studied intensively, our review clearly shows that some of these 'non-canonical' members can specifically rescue aggregation caused by the distinct proteinopathies, some of which have now also been demonstrated to be effective in mouse models.
Another approach for intervention in S1P-related pathophysiology has been put into practice by a mAb (monoclonal antibody) that binds and neutralizes S1P and was shown to be effective in mouse xenograft and allograft tumour models [ 6, 11] as well as in a mouse model of wet AMD, i.e. choroidal neovascularization [ 12].
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His career-long quest had been to develop a vaccine against cancer for humans, having shown 20 years ago that such a treatment could be effective in mice.
Separately from Sirtris's investigations, a research team led by Tomas A. Prolla and Richard Weindruch, of the University of Wisconsin, reports in the journal PLoS One on Wednesday that resveratrol may be effective in mice and people in much lower doses than previously thought necessary.
It's not the only drug though being tried out CBLB502 has been shown to be effective in mice and monkeys.
A Chagas vaccine (TcVac3) has been found to be effective in mice with plans for studies in dogs.
These concentrations have been shown to be effective in mice (MW DeGregorio, unpublished results).
Once a few treatment regimens have been shown to be effective in mice, they should be tested in ferrets.
To this end, we examined whether TNF treatment would also be effective in mice that have been rendered osteoporotic by oophorectomy.
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