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A commentary published alongside the Nature paper, by Ian Wilmut, the man who produced the first cloned sheep (using somatic-cell nuclear transfer to do so), referred to Dr Yamanaka's technique but said, "There is so far no sign that this approach could be effective in human cells".Well, there is now.
These findings suggest that maternal NAC therapy may be effective in human pregnancies associated with maternal/fetal inflammation, such as preterm rupture of membranes and chorioamnionitis.
In particular, it was shown to be effective in human graft-versus-host disease [48].
Glucosamine sulfate was also shown to be effective in human OA osteoblasts [ 24].
If a treatment can be effective in this model, it is more likely to be effective in human MSUD.
CsA has also been demonstrated to be effective in human atrial tissue models of simulated IRI [ 49].
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These drugs have achieved striking results in reversing cancer in mice and have raised hopes that they will be effective in humans.
Although he's hopeful that the drug will be effective in humans, he's not holding his breath.
If a similar drug could be found to be effective in humans, then the researchers believe it would need to be prescribed in a similar way to statins.
A: In the primate model, such a wide variety of these vaccines work that I really believe one of them is going to be effective in humans.
Still, the proof-of-concept is encouraging: "If it works in the mouse, there's no biological reason to think it wouldn't be effective in humans," says stem cell researcher George Daley of Harvard Medical School in Boston.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com