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To date, ribozymes have been reported to be effective in cell culture against a variety of RNA targets, including viral, endogenous, and transfected sequences.
Likewise, low-dose erlotinib (25 mg/day) was found to be effective in cell lines and in clinical practice [10].
These results were in general agreement with the combination analysis data and confirm that this combination appeared to be effective in cell lines derived from multiple tumour types.
There are reports suggesting that in diabetic rats, the administration of plant extracts can be effective in cell regeneration and restoration of islet size, even producing cell hyperplasia [ 29, 32, 33].
In total, 18 drugs were screened (see Table 5): two of these were specific alternative inhibitors; 15 were compounds either approved for human cancer treatment or shown to be effective in cell culture; and one control treatment of clotrimazole, a fungicide not known to have anti-cancer properties.
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Compounds demonstrated to be effective in cell-based assays were then tested in Drosophila and zebrafish models of Huntington's disease [8].
D/N signaling is known to be effective in cells being in direct contact with the ligand-producing cells (Wang, 2011).
As there are several commercially available EGFR inhibitors available (such as Iressa and erlotinib), we questioned whether targeting this receptor tyrosine kinase would be effective in cells in which it is highly expressed.
Our findings that KRASM cancers could respond to combinations of MEK + AKT inhibitors is interesting and other groups have shown MEK + AKT inhibitors could be effective in cells with mutations both in KRAS and PIK3CA [ 24].
With appropriate cytosolic delivery systems, Morpholinos are effective in cell culture.
The results revealed that M → M + G treatment was effective in cell apoptosis induction.
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