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Furthermore, cytoplasmic staining was ignored as imaging antibodies will not be easily internalized and will have to bind to receptors on the outside of the cancer cells.
Since NIRF antibodies will not be easily internalized, intracellular molecular targets relevant for optical detection of breast cancer have so far been ignored.
MPIOs can be easily internalized by several types of cells and allow for labeling capacity up to hundreds of picograms of iron per cell without affecting cellular viability [ 35].
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Furthermore, the pDNA vectors were easily internalized intodifferent cell linesand targeted delivery to mitochondria was confirmed by fluorescence confocal microscopy.
That idea was easily internalized, and brought together in one heroic quest De Quincey's opium visions and the writing that he concocted to describe them.
S-Lauroylglutathione (lauroyl-SG) and S-palmitoleoylglutathione (palmitoleoyl-SG) were easily internalized into the cells and they significantly reduced Aβ42-induced oxidative stress in human neurotypic SH-SY5Y cells.
5 The term "bioavailability" refers to "the extent to which the lead is in a form which is easily internalized by the body, i.e., the extent to which it is in a form which can be physiologically transported through the lungs, gastrointestinal tract, skin, etc. and absorbed into the bloodstream.... .. R.R. at 313a-314a.
When these TAT-incorporated nanogels were incubated with 3T3 cells, they were easily internalized and almost exclusively in the cell cytoplasm as shown in Figure 3b.
The progress of the technique in vivo relies primarily on the choice of cell labels that are easily internalized by cells and can be readily visualized by MRI.
Similar to our previous study [ 14], PCV2 was easily internalized in the cytoplasm of AMs but caused no noticeable cell death; and PRRSV displayed a low infectious rate but severe cytopathic effect and strong TNF-α induction in AMs.
Previous reports [ 10, 12, 14] have shown that NPs with small diameter and large surface area/volume ratio induce higher cytotoxicity in comparison with the larger NPs, probably because they were easily internalized by the cells, and, at the same weight/volume of the medium, they were also administered in larger number.
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