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It is fundamental for normal differentiation and tissue homeostasis, and seems to be dysregulated in virtually all cancers.
The R-point is fundamental for normal differentiation and appears to be dysregulated in virtually all cancers.
Since the first characterized miRNAs, miR-15 and miR-16, were found to be deleted in patients with chronic lymphocytic leukemia (CLL) in 2002 [61], a large number of miRNAs have been found to be dysregulated in virtually all cancers [62], [63].
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Our bioinformatic pathway and network analysis predicted that mitochondrial genes may be dysregulated in motor neurons of AR100 mice.
MicroRNA-134 (miR-134) has been demonstrated to be dysregulated in glioma tissues.
Although granulocyte and monocyte differentiation is known to be dysregulated in cancer7,8,9,10, we do not fully understand how tumors affect cDC differentiation.
It is plausible that some of these miRNAs may also be dysregulated in other autoimmune diseases.
Tregs appear to be dysregulated in CTCL.
FoxO1 acts downstream of the insulin-dependent signaling pathways, which are dysregulated in diabetes22.
This study demonstrates that interferon response genes are dysregulated in cancer cells.
Also, miRNAs are dysregulated in tumors and function as tumor suppressors or oncogenes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com