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Our result is consistent with the interpretation that METH-mediated learning deficit might be due to modification of hippocampus-VTA loop and that augmentation of GABAA receptor function in the shell NAc may provide a new therapeutic target for alleviating METH-induced memory deficits.

In C6 cells, the low levels of NF-κB p65 activity could therefore be due to modification of this subunit by BG-12.

We speculate that the lack of correlation could be due to modification of NKp30 ligand(s) in these cells, leading to their altered recognition by the fusion proteins.

The presence of such aberrant tRNA genes in mitochondrial genomes could be due to modification of tRNA secondary structure by replication slippage [ 18], or selection for mitochondrial genome minimization [ 19].

However, this does not seem to be due to modification of Tyr-337 (or contiguous Tyr-147) since the enzyme activity was practically unaffected after site-directed mutagenesis of these two residues.

Note that similar variation in skin color could also be due to modification of the thickness or density of the yellow pigment layer without any change in the structural component.

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These changes in functionality are suggested to be due to modifications in the total phenolic content and profile by phenolic oxidation or polymerization caused by thermal processing.

Variations in correlation among the versions of the SenseAmp method may be due to modifications to the structure of the T7 promoter/cDNA template.

This may be due to modifications to substrate/polysaccharide chain confirmations, as has been seen in starch-binding proteins [ 91], along with other possibilities such as steric occlusion of preferred binding sites and others.

In the subsequent period of times studied, for example, 24 hours, the changes observed in the host cell could be due to modifications needed to maintain a productive infection once the parasite entered the cell.

This could be due to modifications in the nuclear-pore complexes or in the activity of the transport receptors (karyopherines/importins/exportins) or changes of the TFAP2α protein itself.

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