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The observed changes in color of the sera and livers may be due to modest increases in circulating bile acids seen in these mice (Cre, Cre and sCre were 17+/−9 µmol/l, 21+/−6 µmol/l and 54+/−15 µmol/l, respectively) [10] or an accumulation of the green pigment, biliverdin, a breakdown product of heme [16].
The lack of a significant association between body-fat measures and hip JSN among men may be due to modest sample size, and may also reflect a sex difference in the effect of obesity on hip OA.
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For comparison, dotted line shows QNMDA inhibition in PLE+ and PLE− neurons in the absence of CM-MK801, which is due to modest synaptic rundown.
This discrepancy may be due to our modest sample size, but it is consistent with findings that colour vision deficits are under-represented in high-level cricketers in England [57] and with another study [58] in which fewer first-grade cricketers than expected were found to be colour-vision deficient.
The difference in arrest rates does not appear to be due to the modest difference between police- and public health-detected clients in local residence.
Taken together, these observations and the fact that we observe significant changes in miRNA expression suggest that the changes in miRNA expression are unlikely to be due to the modest effects observed in different lymphocyte subsets in our age groups.
This may be due to the modest sample size and/or because T2D cases and NGT controls were not specifically selected from families with or without history of diabetes, respectively, and/or because T2D cases and NGT controls were not matched for BMI.
While this lack of association may be due to the modest sample size or hidden biases such as population stratification, it may also signify that other SNPs in the same genes or located in different genes could be associated in the North African population.
This relatively low use of acetaminophen for chronic knee OA might be due to the modest efficacy of long-term intake of this drug to alleviate pain [ 18].
Conflicting reports of imatinib-induced cardiotoxicity may be due to the modest or short-term cardiac monitoring associated with human anticancer clinical studies.
Part of the inhibition of PDGFRα could be due to a modest decrease in surface PDGFRα expression resulting from NRP1 knockdown, although we think this unlikely to wholly explain our results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com