It is possible that the age-related changes may in part be due to alterations in signalling within the GI tract.
This may be due to alterations in serum lipid metabolism during sepsis, modulating the host response to inflammation in critically ill patients.
Thus, vertebral fragility may not only be due to alterations in bone architecture but also to modification of collagen cross-link patterns thereby influencing bone's mechanical behavior.
This could be due to alterations in the tumor itself resulting in its impaired recognition by the immune system, by the tumor microenvironment, and by the dysfunction of immune cells of patients with RCC.
However, P2Y1R mRNA levels do not change with age, suggesting that the age-dependent decrease in the [Ca2+]i response to P2Y1R agonists may be due to alterations in the activity of a component of the P2Y1R signalling pathway.
Alternatively, PCD induction in atips1 may be due to alterations in sphingolipid metabolism as shown previously for the acd5 and acd11 mutants [55], [56].
The mechanism for the increased phosphorylation of Pyk2 is unknown, but does not appear to be due to alterations in the expression of PTP-PEST.
These results showed that the delayed life cycle of attB-Ads must be due to alterations in subsequent steps to replication.
It is tempting, therefore, to speculate that some of the alterations observed in MKS3 mutants may be due to alterations in the Wnt signaling pathway.
Differences in function could be due to: alterations in the bZip dimerization domain, differential distribution of conserved cysteines and the lack of the putative interaction motif pair B2-E2.
For example, substrate stiffness affects the extent of cell spreading and hence cell shape, indicating that cell responsiveness to substrate stiffness in 2-D could be due to alterations in cell shape.
