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The immunosuppressive effect of TCDD has been shown to be due to activation of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor in CD4+ Th17 T-cells, and upregulation of IL-22 expression [ 30].
Pain development of FM patients during the stress test may be due to activation of several stress-associated physiological systems, and not obviously caused by muscle activity in isolation.
This pain-related hypoesthesia might be due to activation of descending inhibitory systems [60].
Authors suggested that PGE2-induced headache might be due to activation and sensitization of cranial perivascular sensory afferents [49].
These symptoms are the result of activation of the cranial parasympathetic system, and are believed to be due to activation of the trigeminal afferent arm of the trigeminal-parasympathetic reflex [4].
Thus, increased ATP/ADP would be due to activation of the EM pathway (by consumption of starch-derived glucose) and TCA cycle (by electricity generation) at pH 7.0 (Fig. 4).
The underlying mechanism was found to be due to activation of capases-9, -8, -4 and -3.
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Therefore, we examined whether an increase in p21 expression in HFF-MBPsi-4 was due to activation of p53 transcriptional activity.
We suggested that this was due to activation of the parasympathetic system.
In addition, its acute anti-nociceptive effect was due to activation of NO-cGMP-PKG-KATP channels [16].
Fish serum causes hemolysis of heterologous red blood cells, which is due to activation of alternative pathway of complement system.
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