Sentence examples for be druggable to affect from inspiring English sources

If there are discreet temporal phases of phenotype these may be druggable to affect neuroprotection.

Should pathogenic anti-LGI1 antibodies bind to specific epitopes, these epitopes could be druggable and lead to effective new epilepsy treatments.

First attempts to determine the druggable genome of an organism, based on counting the number of targets belonging to domains known to be druggable, yielded values in the 10 14% range for the human genome (10).

PERK and IRE1 are considered to be "druggable" and the list of small molecule inhibitors to target these UPR sensors is growing [ 62].

DoGSiteScorer [2] was used to calculate geometrical and physicochemical properties of the ATP pockets and to predict the potential of each kinase to be druggable.

ZipA was predicted to be non-druggable using both structures, while TNF was predicted to be druggable.

Bromodomains are key transcriptional regulators that are thought to be druggable epigenetic targets for cancer, inflammation, diabetes and cardiovascular therapeutics.

This review proposes two new targets that may mechanistically integrate inflammation and metabolic syndrome, have been largely ignored, and are known to be druggable.

In addition, in practical application, incorrectly predicting a site to be non-druggable when it is in fact druggable arguably would be worse than incorrectly predicting a non-druggable site to be druggable.

MDM2 and BCL-XL were correctly predicted to be druggable regardless of which crystal structure was used.

All of these targets are predicted to be druggable based on the cutoff of 0.36 used above.