Sentence examples for be driven by variants from inspiring English sources

Thus, signals of recent positive selection observed nearby polyPSGs are likely to be driven by variants located in their cis-regulatory regions.

Variation in regulatory elements has historically received less attention than that in protein-encoding regions, but the fact that the majority of variants associated with complex disease are found outside of genes suggests that at least some associations may be driven by variants that affect gene regulation [ 6].

This effect appears to be driven by common variants (i.e. variants with a frequency above 11.6%).

It may be driven by rare variants.

Thus, the acquisition of new forms and functions is thought to be driven by rare variants that occur at random, and are enriched during times of stress.

In the enrichment test using Korean GWAS, although the significant signal appeared to be driven by total genic variants, we found no evidence for enriched association of coding variants only with RA.

Only the signal in the DNASE1L3-PXK region is most likely to be driven by a missense variant in DNASE1L3 [ 26 ▪, 27 ▪].

Several SNPs in this cluster are correlated with these variants at r > 0.5, including rs10069690 that was previously reported to be associated with ER –ve breast cancer (9), suggesting that the prostate and breast cancer risks may be driven by the same variant(s).

The residual FRR for breast cancer may be driven by yet unidentified common variants that have similar patterns to those that have already been identified, that is more strongly associated with ER-positive than ER-negative disease, while GWAS restricted to ER-negative or BRCA1 mutation carriers may identify susceptibility variants associated with ER-negative disease.

Furthermore, GWA studies of cancer risk have observed that variants in the TERT region influence risk for multiple cancer types, including breast (22), colorectal (23), lung (24), prostate (24) and ovarian (22) cancer, although these associations do not appear to all be driven by the same causal variant.

This synergy seems to be driven by a joint effect between HFE variant and HMOX-1 L alleles. HMOX-1 L alleles