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Cancer resistance to therapy occurs through a selection process generally thought to be driven by mutations.
BACKGROUND: Neoplasia can be driven by mutations resulting in dysregulation of transcription.
It is also thought to be driven by mutations in hedgehog protein pathway.
This is because many upstream causal factors may be driven by mutations and events with subtle responses at the transcriptional and post-translational levels.
Neoplasia can be driven by mutations resulting in dysregulation of transcription.
A few malignancies seem to be driven by mutations in only one or a few genes, suggesting a unique pathway, pathognomonic to the disease.
Similar(53)
Codon use differs between the three genotypes and appears to be driven by mutation rather than selection.
Some amino acid residues in or near helix A sequences in these Rf genes are under diversifying (positive) selection, apparently in response to changes in the target RNA sequences that may be driven by mutation and recombination.
A few years ago, Jihye Yun, then a graduate student at Johns Hopkins University in Baltimore, Maryland, found that colon cancer cells whose growth is driven by mutations in the gene KRAS or a less commonly mutated gene, BRAF, make unusually large amounts of a protein that transports glucose across the cell membrane.
Evolution is driven by mutations, which lead to new protein functions but come at a cost to protein stability.
These findings indicate that approximately two-thirds of papillomas are driven by mutations in the PI3CA/AKT pathway.
More suggestions(16)
be increased by mutations
be driven by brands
be incurred by mutations
be deleted by mutations
be driven by sales
be driven by principles
be driven by data
be disturbed by mutations
be rescued by mutations
be altered by mutations
be tested by mutations
be bypassed by mutations
be maintained by mutations
be driven by results
be driven by people
be conferred by mutations
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Justyna Jupowicz-Kozak
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