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Also, this arrangement cannot be driven by charge repulsions, as the carboxylic acid groups are not ionized at pH 2, nor because of excluded volume interaction, as the distance between them is too large (ordering can occur in the case of closely packed particles).
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The work described here suggests that interactions with lobe 2 that are driven by charge lead to higher enthalpies of binding and lower entropy (possibly accompanied by lower dynamics in the ligand receptor complex).
Although there are several proposed mechanisms, they share the common theme that proton uptake to the heme sites and release into the P-side of the membrane are driven by charge compensation during ET events from the low-spin to high-spin heme.
The whole demand for reform of Social Security has been driven by charges that the system is unsustainable in the long run -- now, suddenly, we're supposed to accept a "reform" that actually cuts the system's remaining life by 14 years?
Due to the high net charge of these regions, it was suggested that the unfolding is driven by charge-charge repulsion [3].
Both cyclic nucleotides bind to the protein through strong enthalpy driving forces, with enthalpy values of −12.5 versus −12.4 kcal/mol at 30°C, suggesting that binding is driven by charge-charge interactions, most likely between the phosphate groups and the highly charged residues of the PBC.
The cap means that any future increases in premiums will be driven by higher charges from doctors and hospitals, not by increases in Blue Shield's operating margins.
Proton translocation appears to be driven by conserved charged amino acids that are located along the central axis that traverses the four proton pumps (Baradaran et al. 2013; Hirst 2013; Zickermann et al. 2015).
It can be driven by those in charge.
Moreover, accumulation of the drug in brain continued beyond the time of the experiment (7 days) and is likely to be driven by the presence of negatively charged phospholipids.
At the residue level, the adoption of this '17+ k↔21− k' conformation may be driven by both the alignment of oppositely charged K16 and E22 and the stacking arrangement of Q15 and N23 (Table 2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com