In parallel with those observations, many lines of evidence suggest that cancers may be driven by alterations that are epigenetic in nature, that is, they do not alter the primary DNA sequence (McDonald et al, 2011; Timp and Feinberg, 2013).
The changes in EYA3 expression that we report are unlikely to be driven by alterations in the duration of the nocturnal melatonin signal, as this hormone continues to report the prevailing photoperiod, irrespective of circannual phase [ 10].
The mutations of these genes seem to have different impacts on cellular functions, manifesting as unique MDS phenotypes and suggesting that MDS phenotypes may be driven by alterations in splicing machinery.
An increased number of circulating plasma cells and the presence of autoreactive T and B cells in the sera of patients with SLE suggest that the disease might be driven by alterations in DCs.
This rapid relapse is driven by alterations in the Aurora B signaling pathway that hyper-stabilize k-MT attachments and is reversible following UMK57 removal.
A study of the genomes of patients with a particularly aggressive form of non-Hodgkin's lymphoma shows that many cases are driven by alterations in the JAK/STAT3 cell signaling pathway.
In their study published in the Oct. 28 New England Journal of Medicine, a multi-institutional research team reports that daily doses of the investigational drug crizotinib shrank the tumors of more than half of a group of patients whose tumors were driven by alterations in the anaplastic lymphoma kinase (ALK) gene.
The first-ever systematic study of the genomes of patients with ALK-negative anaplastic large cell lymphoma (ALC L, a particularly aggressive form of non-Hodgkin's lymphoma (NHL), shows that many cases of the disease are driven by alterations in the JAK/STAT3 cell signaling pathway.
Cancer development is driven by alterations in both genetic and environmental factors.
This component is driven by alterations in signaling molecules, such as CBL, CBLB, FLT3, JAK2, LNK, MPL, NF1, PTPN11 or RAS.
