Sentence examples for be downregulated in primary from inspiring English sources

SLC22A3 was also found to be downregulated in primary HCC compared to TST (p < 0.001).

For example, miR-204 was reported to be downregulated in primary RCCs and was found to be further downregulated in the current analysis.

miR-215 has also been shown to be downregulated in primary RCCs (White et al, 2011a) and colon cancers (Braun et al, 2008).

Although, the concentration of let-7a wasignificantlylowerwer in GC patients than in controls, contrary to our expectation, we have also found that a certain miRNA that was reported to be downregulated in primary cancer tissues showed a lower plasma expression level in oesophageal cancer patients (data not shown).

An interesting observation is that a number of miRNAs that were reported to be downregulated in primary RCCs (White et al, 2011a) were reported to be further downregulated in metastatic RCCs, suggesting that these miRNAs may contribute to both the initiation and progression of RCC and that their progressive downregulation may have a further role in the development of metastatic RCC.

Finally, miR-126 and miR-486-5p miR-486-5p miR-486-5pto be downregulated in primary cancer and in thaveera of NSCLC patients in several independent studies (bothi et al, 2011; Hu et al, 2010; Shen et al, 2011; Volinia et al, 2006; Yanaihara et al, 2006).

We unravelled novel molecular mechanisms by which cystatin C affects tumor cell invasion demonstrating that cystatin C expression was downregulated in primary prostate tumors compared with benign tissues in 448 patients.

In consideration of above observation that CBX7 is downregulated in primary gastric carcinomas with p16 methylation and CBX7 knockdown does not induce demethylation of p16 in PC3 cells, it is likely that CBX7 upregulation may be sufficient for induction or maintenance of H3K9me3, but not for the establishment of DNA methylation within the p16 locus.

We previously showed that miR-26a is downregulated in primary AML samples.

After Fgfr inhibition the expression of pea3 and atoh1a are downregulated in primary neuromasts.

BECLIN and UBE2B were downregulated in primary AML cells transduced with CREB shRNA.