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PEDF expression has been shown to be downregulated in multiple human solid tumors, including prostate cancer.
Whether MiR-101 is reported to be downregulated in multiple tumors.
In fact, some of them, and their processing components such as the enzymes Dicer1, Drosha, microprocessor complex subunit DGCR8, and RISC-loading complex subunit TARBP2, have shown to be downregulated in multiple cancers.
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It has been reported that miR-449a is downregulated in multiple maglignancies.
Real-time PCR and western blotting analysis showed that FPPS was downregulated in multiple tissues in the transgenic mice.
Specifically, miR-101 is downregulated in multiple tumor types, and miR-101 overexpression impairs tumor cell expansion.
miR-34a is one of several miRNAs that are downregulated in multiple cancers [ 26] and has been shown to be transcriptionally regulated by p53.
Our study shows that the entire miRNA cluster miR-379/miR-656 cofprising of more than 50 miRNAs is downregulated in multiple human cancers.
Ang-2 is overexpressed and is prognostic in a number of tumor types, including CRC 14. Ang-2 biology is known to be VEGF dependent and has been shown to be downregulated in response to anti-VEGF therapy by multiple groups, including our own 15, 16.
All mitochondrial DNA-encoded genes that were included in the arrays (ND1, ND2, ND3, ND5, ND6, COX1, CYTB) were downregulated in initial multiple sclerosis lesions (Table 3).
Expression of ARHI is downregulated in ovarian cancers by multiple mechanisms.
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