Sentence examples for be downregulated in a from inspiring English sources

Of particular significance is that PTEN has been demonstrated to be downregulated in a mouse model of Purkinje cell degradation, a hallmark of autism neuropathology [69].

In his study, Dharap[28] reported miR-29b (at 3, 6 and 24 h) and miR-137 (at 24 h) to be downregulated in a MCAo adult rat model, while Lei[33] reported the same findings in a TBI adult rat model at 6 h post injury.

Although NDRG1 has been reported to be downregulated in a variety of cancers which includes the cancers of prostate, breast, colon and oesophagus there are also reports that NDRG1 is upregulated in hepatic, pancreatic and kidney cancers [10], [11], [40] [43].

We next addressed the issue of whether Dicer could be downregulated in a bone metastasis model of breast cancer cells.

For example a metabolite shown through conventional untargeted metabolomics to be downregulated in a disease, could be administered as a stable isotope, and reverse the disease phenotype.

In renal cell cancer, PTEN gene expression has been shown to be downregulated in a large percentage of cases, presumably by epigenetic silencing (Brenner et al, 2002; Velickovic et al, 2002).

ROCK-1 mRNA and protein were downregulated in A-498 and 769-P cells after si-ROCK-1 transfection.

In addition, CXXC4 was also downregulated in tissues with lower EZH2 expression, indicating that CXXC4 can also be downregulated in an EZH2-independent manner.

As expected, in the presence of 2 μM of [C]-PDS the expression of quadruplex containing genes was found to be downregulated in an irradiation time dependent manner.

Dkk3 has also been proposed to act as tumor suppressor, as it is downregulated in a number of tumor cells (Table 2).

Significantly, we also found that CHMP7 was downregulated in a SBMA human cell model derived from induced pluripotent stem cell (iPSCs) reprogrammed from patient fibroblasts to generate patterned ventral spinal cord motor neuron precursor cells (pMNs).