When considering GLP-1RAs, the author's patients usually receive the longer-acting GLP-1RAs, liraglutide and EQW, instead of exenatide BID, because they are dosed less frequently and have a superior effect on fasting glucose [ 22, 27].
The efficacy of palivizumab at doses <15 mg per kg, or of dosing less frequently than monthly throughout the RSV season, has not been established.
In addition, haemoglobin response data suggests that, in this patient population, dosing less frequently than the 3 times weekly doses used for rHuEPO may be possible while improving anaemia.
Natural protein, number one, is expensive to manufacture and it has to be dosed pretty frequently — once daily".
The MEK inhibitor AZD6244 is dosed more frequently and the PLCγ inhibitor less frequently.
They are less likely to be prescribed an angiotensin converting enzyme inhibitor or a β-blocker (Sin and McAlister 2002; Maggioni et al 2003), and have uptitration of these agents to the recommended doses less frequently (Komadja et al 2003).
All the rest administer lower dosages, either because of a lower unit dose or because the same dose is given less frequently.
Peripheral neuropathy, arthralgias, myalgias, and dermatologic toxicity can be encountered less frequently, rendering dose reduction necessary [ 14- 16].
Perhaps, in the current care paradigm, abatacept and TNFi can also be provided less frequently or in lower doses as stated in protocols.
