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Therapeutic hypothermia, however, did not attenuate the activation of the p38 and JNK pathways, but activated the ERK pathway, which seemed to be dose dependent with the duration of therapeutic hypothermia.
These mechanisms are likely to be dose dependent with low gemcitabine doses preferentially inhibiting viral replication and higher doses inhibiting both viral replication and cell proliferation.
Indeed, the protective effects of TNF-α have been shown to be dose dependent with too high levels associated with increased TB pathology [16].
The increase in blood glucose levels due to Gcg-XTEN was found to be dose dependent, with doses 0.6 nmol/kg or lower showing no significant increase in blood glucose (Fig 6C).
This suppression appears to be dose dependent, with median nadir at approximately 14 days.
Enamel phenotypes of ENAM mutations may be dose dependent with generalised hypoplastic amelogenesis imperfecta segregating as a recessive trait and localised pitting as a dominant trait.
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Hemodynamic changes were dose dependent with maximal effects at 20 and 50 mg per hour.
This response does not depend on the presence of additional mitogen or antigen as has been previously reported and is dose dependent with respect to IL-2.
The effects were dose dependent, with the treatment of 2.5 μg/L cypermethrin showing more acute effects than that of 1.25 μg/L of cypermethrin.
The inhibitory effects of PZ-128 on platelet aggregation stimulated by the protease-activated receptor-1 agonist SFLLRN (8 μmol/L) at 30 minutes to 6 hours were dose dependent with 20%to40%0% inhibition at 0.3 mg/kg, 40% to 60% at 0.5 mg/kg, and ≥ 80%to100%0% at 1 to 2 mg/kg.
Generally the effect of psychedelics on locomotion is dose dependent, with stimulation at low doses but locomotor inhibition at high ones.
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