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Sporozoites excysted from solar irradiated oocysts consistently showed increased exocytosis in comparison to those of the dark controls (Fig. 7) however, it did not appear to be dosage dependent, with increased solar insolation (T2) not consistently resulting in augmented exocytosis.
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Further, at the transcriptome level, the effect of radiation on gene expression may be dosage dependent.
These data demonstrate that 5-aza-CdR induced DNA SSB or DSB is dosage dependent.
Moreover, expression of apomixis is dosage dependent.
This is important as effects of some angiogenic proteins are dosage dependent.
Furthermore, the contribution of Nanos3 to PGC maintenance and survival seems to be dosage-dependent in mice, as a model with attenuated Nanos3 transcript levels displayed markedly reduced numbers of PGCs [ 39].
However, as such inhibitive effects were found to be dosage-dependent in this current study, further investigations are required for the optimal dosage of MMP-3 inhibitor.
As shown in Figure 4, ROS activation was dosage-dependent when IDA was combined with a constant concentration of TPL (IC20: 5 nM).
This effect was dosage-dependent (Figure 3c).
This loss-of-function phenotype is dosage-dependent.
Conversely, the PLA2G7 279F allele was associated with a reduced CAD risk of 0.80 (0.66–0.97, p = 0.02), and the effect tended to be gene-dosage dependent, with an OR 0.79 (0.64–0.98) and 0.69 (0.33–1.44) for carriers of one and two copies of the 279F allele, respectively.
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