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The mechanisms by which genetic variants are correlated with ANA positivity may be diverse and require further study.
The value of such a paper is to use quantitative models to make a qualitative point, that the outcome of biologically based therapies can be diverse and require model-based thinking as a guide to experiment.
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In the ICU, indications for renal replacement are diverse and require modification based on the clinical situation.
The mechanisms behind these effects are likely to be diverse and will require further investigations in vivo.
The pathways activating EMT and stemness properties in intestinal tissue (Yan et al, 2012; Zhu et al, 2013) might be diverse, and further studies are required.
In fact, big data is diverse and unstructured, therefore it requires special tools and techniques that go beyond traditional information system and relational databases solutions.
The effects of EPA on catabolic stimuli are diverse, and further research is required to determine under what conditions these pathways are activated and how to optimise the inhibitory effect of EPA on muscle degradation.
The patient cohort is diverse and strict diagnostic criteria are absent, requiring a high degree of clinical judgment and collaboration between specialists when treating such patients.
Clinical problems requiring bone regeneration are diverse, and no single regeneration approach will likely resolve all defects.
However, the exact mechanisms by which antisense transcripts regulate their sense partners are likely diverse and require further studies.
Taken together, these results suggest that host pulmonary CMI responses to the ts cna1 mutant that is eventually eliminated from the host without the induction of IFN-γ appear to be dose-dependent, diverse, and require further stimulation to induce C. neoformans-specific Th1-type cytokine responses to resolve subsequent experimental pulmonary cryptococcal infections.
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