The two subgenomes are distinguished by expression of retained duplicate genes and gene loss rates.
Lower down the bulge, a third population of CD34 positive cells is distinguished by expression of Lgr5 (Fig 2), originally identified as a marker of intestinal stem cells (Jaks et al, 2008).
Supporting studies by Petersen and colleagues [ 48] have shown that a subset of suprabasal breast luminal epithelial cells that are able to generate themselves, as well as differentiated luminal epithelial cells and myoepithelial cells, and are able to form terminal ductal lobular unit-like structures are distinguished by expression of cytokeratin 19.
The cancer cells (except LuCaP49) could be distinguished by their expression of any one of the cancer genes AMACR, PCA3, AGR2; their expression levels were variable.
However, our data also demonstrate that tumour cells and endothelial cells can be distinguished by their expression of HPA1; the high levels of this enzyme on tumour cells compared to its weak expression on the endothelium is likely to contribute to the differential reactivities of the HS found on the surfaces of these two cell populations.
They typically lack myeloid antigens and can be distinguished by the expression of CD123, CD303, and CD304 (Cella et al., 1999; Mathan et al., 2013).
Aside from the site of mitosis, APs and BPs can be distinguished by the expression of distinct transcription factors, i.e. Pax6 and Tbr2, respectively [12], [13].
Ductal carcinoma in situ and lobular carcinoma in situ can be distinguished by the expression of E-cadherin.
By immunocytochemistry, human cells of proximal and distal origin can be distinguished by their expression of different cell-cell adhesion proteins [ 18].
Germinal zones in the cerebral cortex of developing ferrets can be distinguished by the expression patterns of progenitor marker molecules such as Sox2, Pax6 and Tbr2.
