The biopsies of subjects with FSGS, MGN, and MCD could be distinguished from control biopsies based solely upon the expression of the 11-gene signature, supporting the conclusion that this 11-gene set is part of a common pathway linking proteinuria to gene expression in the kidney.
More than 10 histologic variants are known, some of which are distinguished solely based on a peculiar microscopic appearance and others appear to have distinct clinical and prognostic characteristics.
In all feature conditions, trials could be distinguished solely in terms of a single visual feature, namely color or shape.
However, it is important to recognize that two isoforms differing by such nominal masses cannot be distinguished from post-translational modified isoforms based solely on mass differences.
We tested if these findings could be extrapolated to other proteinuric diseases beyond IgAN and found that all forms of primary glomerulonephritis (n = 33) can be distinguished from controls (n = 21) based solely on the expression levels of these 11 genes derived from our in vitro proteinuria model.
It would be interesting to determine whether RPG promoters could be distinguished from other types of promoters based solely on the spatial distribution and frequency of the motifs described here, but such an investigation is beyond the scope of the current work.
Biopsies from patients with IgAN (n = 25) could be distinguished from those of control subjects (n = 6) based solely upon the expression of these 231 "albumin-regulated genes".
Hierarchical cluster analysis confirmed that renal biopsies from healthy donors can be distinguished from the renal biopsies of patients with all forms of primary GN based solely upon the expression of the 11 mRNA gene signature (Figure 2).
An alternative way of distinguishing intellectual from physical intuitions is to hold that intellectual intuitions must be based solely on the understanding while physical intuitions cannot be (see above, sec. 3).
POH, other disorders associated with inactivating mutations of GNAS, and POH overlap syndromes are distinguished solely by clinical criteria.
