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Other therapeutic options, including surgery, should be discussed case by case, whenever acceptable.
2.2 In ARDS, the indications for ECMO should be discussed case by case, taking into account the risk-benefit ratio.
Patients receiving regorafenib are off-study (treatment with regorafenib beyond disease progression could be discussed case by case with the sponsor).
Because of the biopsy variability, discordances between biomarker and biopsy results must be discussed case by case before attributing the cause of error to biomarkers or to biopsy.
Given the current level of proof of clinical studies of ECMO in ARDS, of the medical and economic impact of the spread of these techniques, and of the considerable accompanying care load, the indications should be discussed case by case in the light of the individual risk-benefit ratio.
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Proposed exceptions can be discussed case-by-case with your editor.
As a result, some items remain subjective and are meant to be discussed case-by-case and modified as needed according to clinical settings.
Aggressive surgical management in these patients should probably be discussed on a case-by-case basis.
Awaiting further analyses of the EXCLAIM study, extended-duration prophylaxis in medical patients should be discussed on a case-by-case basis.
Until these results are available, ABC2 retains the ABC1 recommendation, which considers that surgery of the primary should not be offered as a routine practice but can be discussed on a case-by-case basis and offered to selected patients.
Therefore, it is currently recommended that adjuvant therapy shall be discussed on a case-by-case basis, considering the risk-benefit ratio for each patient resected from a stage II disease, with strong consideration given to patients with high risk stage II CC as defined previously [ 7, 8].
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