A total of 1460 CpG sites were identified in these EWASs, 62 of them were discovered in multiple (≥3) studies.
At this stage, it would be too early to discuss the implications of this finding as newer miRNAs and other novel smallRNA classes are still being discovered in multiple tissue types [ 29, 30].
Recently, mutation of a novel oncogene, PIK3CA, was discovered in multiple human epithelial cancers, including endometrial carcinoma (Oda et al, 2005; Hayes et al, 2006; Velasco et al, 2006); this oncogene encodes the catalytic p110 α subunit of PI3K in various cancers (Samuels et al, 2004).
Coelocentrum to be discovered in the future.
A striking example of this sensing role of transporters has been discovered in yeast where multiple nutrient transporters appear to control activation of the protein kinase A pathway at the onset of fermentable growth induction.
Seven putative voltage-gated Na+ or Ca2+ channels, two aquaporin-like proteins, and twelve putative VATPase subunits were discovered in all clones using multiple bioinformatics approaches.
CAA should also be suspected in elderly patients with clinical signs of a progressive encephalopathy syndrome with seizures, in which extensive white matter abnormalities are discovered in brain MRI together with multiple CMBs with lobar and subcortical distribution (Fig. 2).
Klotho, the gene encoding the antiaging protein called klotho, was discovered in 1997 when mice developed multiple organ failure and shortened life span resembling human premature aging after this gene was serendipitously silenced.
But scientists began sounding the alarm after multiple outbreaks were discovered in Pacific islands and south-east Asia.
Five weeks after that champagne-filled wedding day, my father called me from Maryland with the news: Michael had been discovered in a car in South Los Angeles, dead from multiple gunshots.
