We have shown that cell-cell variability can also increase the population response time under some conditions, and that it can be disadvantageous when stress durations are intermediate and predictable.
Although one would expect a higher false positive rate for very small variants, it is also plausible that the larger probe size of the NimbleGen data (>60-mers versus 25-mers for the discovery platform) would be disadvantageous when positioned across breakpoints.
Although these adaptations are vital for immediate benefit, many of them are permanent and may be disadvantageous when there is a mismatch between the actual environment and the one predicted in utero [ 1– 3].
Classically, we have viewed limited persistence and rapid reaction rates as desirable fate outcomes, yet there will be instances where these characteristics will be disadvantageous when they create persistent, bioactive products that are difficult to detect via directed analyses.
These phenomena are disadvantageous when performing insertional mutagenesis in filamentous fungi such as A. aculeatus, for which a feasible genetic segregation analysis is unavailable.
Therefore, our conclusion that HGT is disadvantageous when there is accurate genome replication is robust.
However, Paenke et al. (2007) found that nongenetic inheritance is disadvantageous when environmental fluctuations are very rapid and unpredictable from current environmental cues.
Expression microarrays, however, depend on existing genome annotations, which are disadvantageous when domestic animals, such as cows, are used, whose genome annotations are incomplete.
The argument is sometimes made that features of autism that are disadvantageous when they occur as part of a syndrome could be beneficial if they occur in isolation.
