Sentence examples for be directly reprogrammed into from inspiring English sources

Several recent studies have showed that mouse and human fibroblasts can be directly reprogrammed into induced neuronal (iN) cells, bypassing a pluripotent intermediate state.

Mosses, like ferns, have a single stem cell in the meristem, but they are distinct in that differentiated cells can be directly reprogrammed into stem cells without any cell division13, 14.

Strikingly, prospective regulatory cells can be directly reprogrammed into other regulatory cell types simply by loss or ectopic expression of bHLH genes, and male-to-female and female-to-male transformations indicate that the code is instructive for sexual dimorphism.

It is reported that cardiac fibroblasts could be directly reprogrammed into adult cardiomyocyte-like cells (Qian et al., 2012).

In 2010, Ieda et al. reported that postnatal cardiac fibroblasts could be directly reprogrammed into induced cardiomyocyte-like cells (iCMs) by transfection with a combination of three TFs (Gata4, Mef2c, Tbx5, termed GMT) (Ieda et al., 2010).

However, it is unclear if a non-myelinating cell (e.g. NIH3T3 fibroblasts) can be directly reprogrammed into a myelin-gene expressing cell by global epigenetic manipulation.

From the regenerative medicine perspective, in future, new therapies might be designed based on the patient's own cells that are directly reprogrammed into the desired cell types in vitro and in situ.

An alternative strategy to obtain DA neurons that may lower carcinogenic risk is the direct conversion approach where differentiated cells (e.g., fibroblast cells) are directly reprogrammed into DA neurons without going through the fully de-differentiated iPS cell route.

PEFs were directly reprogrammed in 3D collagen scaffolds and typical colonies can be observed by SEM (Fig. S1A).

Four days later, one part of MEFs was directly reprogrammed in 3D collagen scaffolds (3D), another part of MEFs was digested and seeded on 2D cell plates then reprogrammed (3D/2D).

Similarly, many somatic cells can be directly reprogrammed to other cells without a stem cell state.