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If both genes have orthologs in species B we define the interaction g A,1- g A,2 to be directly conserved if their orthologs (g B,1 and g B,2) have the same interaction in species B. We first computed conservation statistics directly from the networks for each species.
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We have also examined whether a uORF is directly conserved in close fungal relatives.
Therefore we performed systematic alanine mutagenesis of A51R residues that were directly conserved or conserved based on charge.
Our results argue strongly that despite extensive binding site turnover and overall sequence divergence, similar regulatory mechanisms govern developmental gene expression even over distances of >350 Myr, and suggest that gene regulatory networks have been directly conserved.
Rewa villagers have told me that getting involved in research offers them an opportunity to be directly involved in conserving their resources.
Although the positions are not directly conserved, one of them might represent the HIF1 binding site inducing promoter activity and AP-2ε gene expression.
These interactions connect two nodes that reside in different modules in species A. Finally, we defined an interaction as 'extended module conservation' when the interaction itself is not directly conserved, but the orthologs of the two genes connected by the interaction reside in the same module in B (see Figure 2a).
The positions of all these amino acids are highly conserved and can be directly inferred from ZF domain sequence.
Local sequence similarities can then be directly interpreted as related regions harboring conserved functional elements.
For DENV NS5, Lys29 (conserved among all four serotypes of DENV) was suggested to be directly involved in the covalent attachment to the GMP [18], [19].
He said his organisation, which was founded in the 1980s, had found that communities which were directly involved in conserving wildlife and were also able to earn a living from it were more keen to protect the animals from poachers.
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CEO of Professional Science Editing for Scientists @ prosciediting.com