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Such effects might be direct effects of the drug causing acute or chronic toxicity, carcinogenicity, or allergic responses.
Goadsby et al. [10] propose that few CNS side effects may represent the unmasking of disease-related symptoms when headache is relieved, and it may not be direct effects of the drug.
An alternative mechanism of action of UV radiation in reducing IPD risk could be direct effects of radiation on pathogen survival.
There may be direct effects of MCM8 and other genes on oocyte meiosis, development or depletion, and ultimately, menopausal age providing a mechanism by which they influence the reproductive lifespan.
This treatment regimen resulted in normal serum T levels in PTM-ARKOs and controls, but serum E2 concentrations were elevated 400-fold compared with nontreated PTM-ARKO and controls; therefore, any effects seen after this treatment are likely to be direct effects of estrogens.
Besides the potential dilution or washing-out of these markers due to joint effusion and/or altered clearance rates [ 11, 12], there may be direct effects of inflammatory mediators and enzymes on articular cartilage turnover and thus on cartilage biomarker levels [ 13, 14].
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Given the timing of these effects, it is unlikely that they are direct effects of the CEO program, as program group members were no longer receiving employment services.
In the meantime, to ensure the alteration of cell proliferation and apoptosis are direct effects of Wnt blocking, we adopted the protocol used in zebrafish study previously [27].
These are direct effects of the presence of blood in the subarachnoid space and also of transient cerebral ischemia.
The question also has been raised as to whether there are direct effects of second generation antipsychotics on insulin secretion.
Only a fraction of these changes are direct effects of HDAC inhibitors, and others are downstream effects, necessitating new protein synthesis.
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