The phosphorylation of Src and Akt at their active sites was decreased in PyMT tumors lacking S14, suggesting that signal transduction through these kinases may be diminished; however, we did not examine the in vivo activities of these enzymes.
Algorithms and systems to facilitate information access and acquisition are still very important and their role cannot be diminished, however they have to get better understanding whom they are used by in order to do their job with the expected efficacy and efficiency - that is to say, they have to be user-centric.
Klopp's hopes of bolstering his squad with the signing of the Shakhtar Donetsk forward Alex Teixeira appear to be diminishing, however, with the Ukrainian club refusing to lower their valuation of the Brazilian.
This justification for the trial is diminished, however, by the passage of 12 years since the crimes were committed.
The show's entertainment is diminished, however, because the exhibits are mostly static.
This enthusiasm was diminished, however, by the terrorist attacks in Paris that left many of us wondering whether COP21 would still occur.
Its external imbalance has narrowed, but a big internal imbalance remains.Even that imbalance may be diminishing, however.
The other lesson is that the importance to the global economy of the big Persian Gulf suppliers, especially the Saudis, has not been diminished, however much we like to regard ourselves as "buffered" by Mexico, Venezuela or even Russia and the other former Soviet republics.
Upon IFNAR blockade we found that on CD11b+ cells, the expression of all costimulatory molecules was diminished, however on CD11c+ cells only CD86 and 4-1BBL expression was affected.
The value of the CDF as a fallback is diminishing however as it has been reformed because of concerns over its finances and can no longer prescribe drugs not approved by Nice.
