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This arrangement suggests that RNase T has to be dimeric for substrate specificity, and agrees very well with prior site-directed mutagenesis studies.
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Class C GPCRs are acknowledged to be dimeric.
The compounds can be dimeric or trimeric.
Class II aaRSs in humans are dimeric enzymes except for ARS which is monomeric.
Finally, the hot spot theory provides a satisfactory explanation for why some P5CDHs are dimeric.
Class I aaRSs in humans are monomeric except for YRS and WRS that are dimeric.
Some viral Bcl-2 proteins are dimeric, but they have distinct structures to those observed for mammalian Bcl-2 proteins.
In solution SecA is dimeric [ 12].
In the crystal structure of SecB the protein is a dimer of dimers, and in solution the tetrameric form is in dynamic equilibrium with the dimeric form and this equilibrium is important for substrate transfer to SecA (Topping et al., 2001; Dekker et al., 2003; Randall et al., 2005).
DAB and Vector Blue Substrate Kit (Vector Laboratories) were used for enzymatic substrate.
They are specific for their substrate.
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