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The rigid support of intracranial probes can be difficult when using animal models, as mounting devices suitable for the probes are either not available, or designed for human use and not suitable in animal skulls.
If a small population of monomer-misfolded SOD1 is pathogenic in FALS, analysis should be difficult when using homodimeric mutant SOD1 like the mutant SOD1G93A as the majority of homodimeric protein has merely a bystander role.
Quantification of protein expression may be difficult when using immunohistochemistry.
Diagnosis of bacterial sepsis in preterm neonates can be difficult when using serum markers that rely on physiological changes because these changes may not necessarily be the result of bacterial infections alone.
Although unambiguous detection of phage contamination at early stages of infection may be difficult when using traditional methods, a newly developed technology of electric bio-chips allows for early detection of bacteriophages in bacterial cultures, even a few bacterial generations before they cause visible lysis of host cells [ 10- 13].
Tying can be difficult when using wires.
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"But the big thing is that pilots can talk at 8 or 9 G's, which is difficult when using a positive pressure breathing system," he said.
Remote sensing of the dynamics of thermospheric neutral particles from ground-based stations is difficult when using other photometric techniques that lack the high-resolution capability of interferometry.
Additionally, also the evaluation if a component is radiographically loose, sometimes is difficult when using this revision technique.
Gathering a complete overview of the contributing causes of (preventable) adverse events is difficult when using retrospective record review.
For example, 100% modulation is difficult when using a cathode-ray tube (CRT) display that utilizes phosphors without sharp temporal cutoffs [ 21, 22].
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