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One complication is that TFs from the same structural family often bind to highly similar DNA target sequences (Luscombe et al. 2000), and it can be difficult to separate sites for different TFs based on the conserved motifs alone.
But Navy officials have said it will be difficult to find a site as good as Vieques for amphibious-assault training involving land, sea and air forces.
Instagram's policy says that it cares deeply about intellectual property rights, but users say it can be difficult to get the site to delete stolen content, and it doesn't do enough to police theft.
In complete disruption, it might be difficult to identify the site of injury due to shrinkage of injured veins or vein compression by the resultant hematoma.
It's a means of communicating away from prying adult eyes and it can be difficult to know what sites kids are using and how.
Explanations of benefits can be difficult to understand, insurer Web sites cumbersome to navigate, and customer service woefully hard to contact.
The time taken to process blood samples may be difficult to synchronize between study sites as the specific field conditions will inevitably vary.
Medical records can be difficult to maintain at disaster sites.
In particular, relationships matter [ 26, 27] - and the nature of the relationships and the demonstrated willingness and capacity to listen may be difficult to allocate to intervention sites.
WORST: The site can be difficult to navigate and slow to respond.
In the absence of detailed biodiversity information it is difficult to prioritise site-based conservation projects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com