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Even under a Bayesian framework with which updating of the parameter values is naturally implemented, it may be difficult to reliably estimate dynamic ranks of players due to relative paucity of data.
Due to individual variation, it can be difficult to reliably separate P. c. abietinus and P. c. collybita outside their main breeding and wintering ranges.
In addition, non-delusional confabulations are a frequent symptom of dementia and may be difficult to reliably distinguish from delusions [ 28].
It can be difficult to reliably identify the same primary tumor or metastasis in order to describe overall tumor size in a consistent fashion.
On the other hand, it would be difficult to reliably reveal orientation selectivity around other elements (occupying >50% of area in V1), such as singularities, where neurons contained within a single voxel can respond to all orientations.
These features make it a useful tool for visualizing spatially heterogeneous chemical environments, especially for small molecules such as drugs and metabolites, which can otherwise be difficult to reliably label and distinguish from structurally similar compounds.
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However, when the input SNR is low, as evident in Figure 2c,d, it is difficult to reliably obtain chirp parameters corresponding to each bistatic link.
Because the closely related L. corrugis has overlapping morphological characters, including similar colouration in the cap and stem, it has been difficult to reliably distinguish between the two species.
Due to the size and consistency of the embryo, it is difficult to reliably isolate sufficient amounts of lung tissue and separate the heart-lung block.
Experience has shown that it is difficult to reliably detect the two other anti-R5 HIV-1 β-chemokines, CCL3 and CCL5 by intracellular staining.
However, the RSE for the random effect correlation is very high, implying that the correlation is difficult to reliably estimate.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com