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The bill was opposed by Mint Director Robert Patterson, as it would be difficult to refine the silver from melted-down pieces.
It would be difficult to refine this assessment into a quantitative metric of model value, but as a screening tool it is credible to assess that three of the models did not pass the eco-plausibility test (Table 2).
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The ores were low-grade, often varied in content, and were difficult to refine.
But the oil is difficult to refine, and the huge investment required is hampered by the government's insistence on overvaluing the bolívar.
It is difficult to refine the Bre2DBM because there is always some discontinuous residual density around the DBM peptide in the electronic density difference map for the final model.
(See "The Case For $80 A Barrel Oil") According to Global Insight's Ciszuk, even a large increase from the desert kingdom would not necessarily be a boon the oil would be heavy, sour crude, which is difficult to refine and is currently trading at a big discount.
It is difficult to refine a target population for recruitment to the programme on the basis of results reported herein, but larger scale studies might help to identify patients who are likely to remain in the intervention and benefit from it.
However, since establishing an etiologic diagnosis may be an iterative process that increasingly refines diagnosis, it can be difficult to define the time at which "diagnosis" is established.
A double album, Humasyouhitch Sonofabitch underlined his already refined talents, and showed why he might be difficult to market.
The principal solvent was identifiable as benzene from the initial structure solution, but was extremely difficult to refine because it exhibits librational disorder (Fig. 6).
One small interview-based study showed promising results, but because psychedelics are hard to refine to medical purity and offer little profit motive for pharmaceutical companies to investigate them, Green said, forming large-scale regular psychedelic studies is difficult.
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