Sentence examples for be difficult to optimize from inspiring English sources

However, many host-targeted agents are natural products, which can be difficult to optimize using synthetic chemistry alone.

A function that factors in all those forces would be difficult to optimize, but it becomes much more tractable if the forces are treated as acting on each foot at a single point.

The authors emphasized that these adaptations all worked within the parameters of existing microprocessor manufacturing systems, and that it will not be difficult to optimize the components to further improve their chip's performance.

In conclusion, the Reinitz function appears to be difficult to optimize using gradient-based methods.

Phospho-specific antibodies are powerful tools to monitor activity of signal transduction pathways, but their use can be difficult to optimize, especially in the kidney organ culture system.

But that's a complex engineering task that's difficult to optimize.

Several steroidal STS inhibitors have been reported, but steroidal compounds are difficult to optimize and may interact with other targets.

It is difficult to optimize the weights in the neural networks that have multiple hidden layers due to the vanishing gradient issue.

Researchers and entrepreneurs have found ways to coax bacteria or yeast to make many useful compounds, but it has been difficult to optimize such processes so that the microbes produce significant quantities efficiently enough to compete with existing commercial products.

These conflicting requirements and goals are difficult to optimize due to the unknown runtime conditions, such as the availability of the resources and random workload distributions.

However, because of the lack of knowledge on the geometrical and mechanical parameters of the track, it is difficult to optimize the maintenance management.