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However, the decrease in minute ventilation induced by low VT can be difficult to offset by increasing respiratory rate and may induce hypercapnia.
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Furthermore, it would be difficult to define a suitable offset.
In such a case, it might be difficult to achieve normalization of offset by a standard stem since extremely narrow standard stems have a short neck.
It can also be difficult to monitor how the money for offsets is used and to calculate how much carbon dioxide is actually saved.
Japanese automakers are trying to cope, but it will be difficult to cut costs sufficiently, through slashing jobs, output and capital spending, to offset the slump in sales.
Retirements have created vacancies in Democratic seats in five Southern states -- the Carolinas, Georgia, Florida and Louisiana -- and it is going to be difficult to defend them all successfully in a presidential election year, offsetting any gains Democrats can make elsewhere.
The shorter duration of treatment is advantageous and may offset some of the drawbacks, although the optimal duration of treatment will be difficult to ascertain in humans.
But significant changes to the provision could be difficult to achieve because it is estimated to produce $155 billion in additional revenue over the next decade, a major offset.
Although some specialty cocktails may be difficult to price within these parameters due to the cost of ingredients, pricing other menu items higher than the standard mark-up can help to offset this issue.
The details of these changes will be difficult to predict at a regional level, but the development of EWS should allow actions to reduce the incidence of the disease, offsetting any increases arising from the changing climate.
It would appear that even the negatives, which are difficult to find, are offset – the present, relatively anaemic dividend yield of 1.8% has been boosted by a 15% increase to the full year payment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com