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In addition, the ease of inducing proteoglycan loss in vitro (both IL-1 and OSM will initiate GAG loss whether used in isolation or combination) suggests that the loss may be difficult to inhibit once initiated.
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The traditional damping network is difficult to inhibit high & low frequency error simultaneously.
In gupigs with sub-acute bronchitis caused by SO2 gas exposure, coughing is difficult to inhibit with centrally acting antitussives such as codeine.
It is possible that VHH T5 10 has higher binding ability to the linker of coating antigens than VHH T1 4 and VHH T3 15 and this nonspecific binding is difficult to inhibit by free TBBPA.
In murine models of CS-induced emphysema, it can take as long as 24 weeks to develop emphysema [ 34], and it is difficult to inhibit p38 MAPK for such a prolonged period.
The small sample volume allows selective testing of special wax-inhibiting polymers and asphaltenes, which may be difficult to obtain in larger quantities required for other deposition devices.
Because HPAECs were difficult to contact inhibit, subsequent cell cycle analysis using FACS was performed on a synchronous population of human umbilical vein endothelial cells (HUVECs).
Technically, it would be very difficult to inhibit ATM activity only at telomere regions, but this would allow any causal link between telomere dysfunction and SASP activation to be identified.
Thus, some interactions may be more difficult to inhibit than others.
This is no easy task, as transcription factors are notoriously difficult to inhibit with small molecules, and selectivity is also a hurdle, as MYC oncoproteins heterodimerize with MAX, a requisite and related bHLH-Zip protein that dimerizes with other bHLH-Zip proteins (Blackwood & Eisenman, 1991).
First, it is more difficult to inhibit P-gp in the BBB than in other areas; thus, larger doses of inhibitors are required to inhibit P-gp activity.
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