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Although the simulations illustrate that detailed information on tumor growth will be difficult to infer from tumor methylation patterns, this drawback should be tempered by current absence of methods to infer human tumor histories.
But until suitably conserved outgroups are found at the base of the Bilateria, it will be difficult to infer the ancestral bilaterian mitochondrial gene order.
It would be difficult to infer which differentially expressed transcript tags qualify as genes directly involved in response to the drought stress, and as candidates for targeting in genetic improvement programmes.
Yet, since the joint contribution of multiple 'doses' is likely to determine transcriptional outcomes, it may be difficult to infer functionality of a given TFBS in isolation from others.
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Therefore, it is difficult to infer large scale networks using traditional statistical methods, limiting this inference to only a few genes.
If the detected deletions are true, it is difficult to infer whether they existed at the time of original infection, or resulted from a subsequent laboratory adaptation.
"Obviously babies can't tell us about their experience of pain and it is difficult to infer pain from visual observations," said Rebeccah Slater, a doctor at Oxford's paediatrics department who led the study.
Observational database research frequently relies on imperfect administrative markers to determine comorbid status, and it is difficult to infer to what extent the associated misclassification impacts validity in multivariable analyses.
While the composition of the SC lipid matrix is known, the molecular-level details of its organization are difficult to infer experimentally, hindering the discovery of structure-property relationships.
These numbers are grouped into size bins and from these it is difficult to infer the size distribution of private sector firms.
Recent work has shown that the pump-probe signals from melanin in human skin cancers correlate well with clinical concern, but it has been difficult to infer the molecular origins of these differences.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com