Cachectic subjects are difficult to guide through chemotherapy experiencing more severe side effects resulting in progressive cachexia.
Although the differences in the mean responses by treatment were statistically significant, the actual magnitude of the differences was quite small and would be difficult to use to guide clinical decisions.
For lesions between 5 and 10 mm, surveillance of growth should be performed by three-dimensional volumetry, as volume doubling is equivalent to only a 26% increase in diameter, a difference that may be difficult to detect with manually guided diameter measurements.
In crowded museums or outside monuments, it can be difficult to hear a tour guide's commentary above the din of other guides, traffic or neighbors' conversations.
Thus, if envy is interpreted as making a claim about impersonal value, it will be difficult to prevent moral considerations from guiding verdicts about its fittingness.[14] While this does not completely collapse the distinction between envy and resentment, it renders it considerably murkier.
If past investigations into such groups prove to be any guide, it may be difficult to find clear-cut evidence of direct involvement by Pakistani intelligence or army personnel.
The group, chaired by Imperial College London engineering professor John Wood, calls for massive new investments in science and education that, if recent European history is any guide, will be difficult to implement.
Unfortunately, unlabeled aluminum alloys can be difficult to tell apart, and professional identification guides are likely only worthwhile if you are running a business.
If you immediately jump right into reading the dictionary without understanding the pronunciation guide, it can be difficult to figure it out.
Alternatively and least likely, organisms might evolve higher RNase activity to preferentially degrade all guide RNAs; this may be difficult to accomplish without harming overall fitness.
