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Cognizant of its debt and ongoing losses, the company warned investors that "our substantial indebtedness [could] make it difficult for us to satisfy our obligations with respect to our indebtedness, and failure to comply with these obligations could result in an event of default under those agreements, which could be difficult to cure, or result in our bankruptcy".
Overall, we have shown in two independent experiments a significant effect of GA on the survival time of mice, in a model that might be difficult to cure, due to the high infectious load inoculated.
Clostridium difficile infection (CDI) is a common cause of antibiotic-associated diarrhea and can be difficult to cure.
Our hypothesis would suggest that it would be difficult to cure more than 20% of premenopausal node-positive patients with short-course and intensive chemotherapy after surgery.
Infections associated with in-dwelling orthopedic devices can be difficult to cure without removing the device, and they are quite expensive to manage (Darouiche 2004).
Although some of these cutaneous lesions respond immediately to antimony treatment, other infections can be difficult to cure and require multiple courses of therapy [ 30, 31].
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Workers at the establishment were particularly interested in infections which were difficult to cure.
Even more problematic, overuse of antibiotics leads to drug-resistant superbugs, which are difficult to cure.
Germs of staphylococcal infections, that are difficult to cure in hospitals, also make at least six infection factors.
Chronic hepatitis B virus (HBV) infection is difficult to cure due to the presence of covalently closed circular DNA (cccDNA).
Sensory nerve disorders are difficult to cure completely considering poor nerve regeneration capacity and difficulties in accurately targeting neural tissues.
More suggestions(17)
be difficult to heal
be difficult to treat
proved difficult to cure
be easy to cure
be difficult to commercialize
be difficult to draw
be difficult to meet
be difficult to check
be difficult to resist
be difficult to sell
be difficult to smell
be right to cure
be possible to cure
be difficult to achieve
be difficult to deal
be difficult to determine
be difficult to forget
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