"By using a sound implementation and following best practices, the malware authors have created a robust program that is difficult to circumvent".
In-built restrictions have been developed within current e-prescribing systems which are difficult to circumvent by prescribers, for example, 'clinical indication' and 'duration' were mandatory data fields therefore these fields have to be completed prior to prescribing antimicrobials.
First, it is an observational study in which the MAP level was not a controlled variable, and as a certain degree of colinearity unquestionably exists between the severity of disease and the MAP level, this colinearity was difficult to circumvent by our statistical analysis.
Indeed, because selective modulation of P-gp in cancer cells (and not at physiologic sites) will be difficult to achieve, attempts to circumvent MDR will need to consider the profound effects on the pharmacokinetics and distribution of concomitantly administered drugs.
But capital controls are not a panacea--they can be difficult to administer, they can be circumvented, and their effectiveness appears to decrease over time.
Compared with existing DNAzyme-based protocols for Pb2+ assay, this strategy circumvented the use of various optical or electrical labels that might be difficult to be synthesized.
And more serious measures, like isolating the offending site by blacklisting it on nearby nodes, would be more difficult to circumvent — but let's be honest, if things reach that level of Gibson-esque cyber-espionage, things may require something more than a technical workaround.
While the former problem can be solved by employing more powerful and robust search engines for peptide identification, the latter one is more difficult to circumvent and can be very detrimental for the quality of HDX MS data and may require significant changes in experimental protocols.
