Sentence examples for be difficult to align from inspiring English sources
Some sequences, particularly ribosomal genes such as 18S, are known to be difficult to align properly [ 98], and these alignment ambiguities can significantly affect phylogeny reconstruction [ 95, 99].
For example, the In 2L t proximal break point in D. melanogaster and D. simulans shows a large number of indel polymorphisms at the break point (Andolfatto and Kreitman 2000) and similar results are found for the In 3R P break point (Matzkin et al. 2005), suggesting that reads from such a rearrangement break point would be difficult to align to the reference with current-generation aligners.
That scuppers any possibility of using quantum cryptography with handheld devices which would obviously be difficult to align.
For instance, laser systems can be difficult to align, sensitive in heavy fog, or cause eye damage, explains Bill Goodson, president of sensor manufacturer Goodson and Associates.
Non-coding spacers can be difficult to align thereby limiting their utility in phylogenetic studies at higher taxonomic levels [20].
In common with other studies generating and analyzing whole mtDNA sequences for interspecific comparisons (e.g. [23]) we noted that the control region tends to contain sites with missing data and because of its high rate of evolution can be difficult to align among species.
From the perspective of land plant alignments, matK is also problematic, as it was difficult to align seed plants with other land plants (e.g., the seed plant alignment took about two person days to complete and carefully check for the current small sample of taxa).
Alignment of the TCP and R domains is unambiguous across taxa, however, the intervening region is difficult to align; therefore, we omitted ambiguous portions of this region from the alignment.
Traditional internal alignment accuracy decreases as evolutionary distance increases; different sequences are difficult to align accurately.
These repeats typically generate regions in the alignment with high variability in sequence and length, and that are difficult to align.
