However, it is difficult to affirm whether MAPK activation is a cause or consequence of Mn-induced neurotoxicity.
Drug-induced thrombocytopenia in a setting of ACS is difficult to affirm as there are no specific tests, except for HIT [ 7].
We cannot definitively attribute the improvement of visual acuity only to retinal status as it is difficult to affirm that we performed a clear lens extraction rather then a cataract surgery.
However, it is difficult to refute or affirm categorically the imprinted status of a gene, particularly in the human species, as this phenomenon can be very restricted in its temporal and/or spatial profile.
As regards DIC, no gold standard exists for the diagnosis of this condition and is also difficult to affirm especially in liver failure.
Together with the wider debates surrounding the influence of the classics on young readers, Tyrwhitt's attack proved to Symonds that it was becoming increasingly difficult to affirm the ideal of Greek love, as the pedagogic Eros was conflated with the corruption of youth.
This has been affirmed by the case study, which required specific experience which is difficult to derive from documentation only.
From a very early age, in moments of reflection on death, life has always shown up to me as something to be regretted, a cruel joke, something difficult to affirm.
Thus, it appears difficult to affirm that hallucinations exist outside the scope of psychosis.
Drug-induced thrombocytopenia is also hard to affirm.
