"I think payers will say, 'If the product works and it creates value, we will reward you for it,' " said Anthony Farino, a pharmaceutical industry consultant at PricewaterhouseCoopers. " 'If not, we won't reward you.' " It is far too soon to tell whether such a pricing paradigm can actually work, in particular because it can be difficult in many cases to measure how well a drug is working.
This can be difficult in many tropical areas because the growth characteristics of endemic species are often unknown, particularly when grown at potentially higher densities in plantations than in natural forests.
Given that such effects may relate to important goals such as protecting human life it may therefore be difficult in many cases to argue that such harms (e.g. stigmatisation or an increased risk of discrimination) would not be proportionate.
When US is the suggested first line for all patients, consideration should be made that this may be difficult in many countries and hospitals due to outsourcing of radiologic services at night, due to the limited availability of US-experienced radiologists, physicians or sonographers 24/7, or due to a combination of all of these factors.
It may be difficult in many cases to decide just what conventions are appropriate and controlling in a situation, but it seems reasonable to suppose that something like Carr's analysis is helpful in understanding the relationship between threats and freedom in conventional contexts.
In other words, the report suggested, it would be difficult, in many cases, to differentiate cancers attributable to Fukushima from cancers developed in the normal course of living in a world where, well, cancers develop for all kinds of reasons -- or don't.
Illiteracy and unfamiliarity are major barriers to condom use, and even now, two decades into the epidemic, it is difficult in many societies to talk about condoms.
Sulfur often easily forms colloid in water solution, and the separation of sulfur from water is difficult in many cases.
Recycling bismuth is difficult in many of its end uses, primarily because of scattering.
It was difficult in many cases to ascertain the site of recurrent lesions in the breast.
Therefore, coordinating second appointments in Lima after initial recruitment was difficult in many cases and impossible in others.
