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Since these signaling cascades may be differentially activated based on the binding specificity and affinity of various ligands to the receptor, RXR activation may not mimic the spectrum of changes that occur when PPAR-specific agonists are used to activate the heterodimer complex.
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We present evidence that certain pathways are differentially activated, based on their global phosphorylation status using a novel computational approach to perform a protein variant of gene set enrichment analysis.
This suggests that the symbiosis signaling pathway can be differentially activated by both rhizobia and mycorrhizal fungi.
Alternately, p53 may be differentially activated in bystander cells.
Thus, cytoplasmic ATM could be differentially activated from the nuclear ATM.
Macrophages can be differentially activated into M1 and M2 subtypes, which have contrasting functions.
Neuroprotective survival cascades seem to be differentially activated under rho kinase inhibition.
Therefore, MAPK can be differentially activated, and its involvement in apoptosis is highly context and model dependent.
At step 3, the smallest p-value is picked as the p-value for this TF to be differentially activated.
This suggests that upstream regulators of apoptosis, such as PKC δ, may be differentially activated in a signal-specific manner.
Interestingly, we found that Wnt and BMP signaling were differentially activated during osteogenic differentiation of BMSCs and ADSCs.
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