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Also, there appear to be differences in DNA site recognition between pneumococcal topoisomerase IV as compared with E. coli gyrase [13].
Mouse ENCODE data showed that there are differences in DNA hypersensitive sites in the gene region, suggesting that there may be differences in DNA accessibility and transcription factor binding in the liver and adipose tissue.
Mouse ENCODE data (Yue et al., 2014) showed that there are differences in DNA hypersensitive sites in the gene region, suggesting that there may be differences in DNA accessibility and transcription factor binding in the liver and adipose tissue.
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To determine if there were differences in DNA adherence to the different projectiles, we examined the effect of removing two of the preparation reagents - spermidine and CaCl2- on the efficiency of transfection.
Although the aim of this study was to examine the extent of DNA methylation genome-wide, we also examined the extent of DNA methylation within these genic regions to investigate if there are differences in DNA methylation patterns between genic and intergenic regions.
Hence, while mouse models are important tools to study the mechanistic background of FA, it is important to keep in mind that there are differences in DNA repair between mice and humans.
We, and others, have demonstrated previously that there are differences in DNA methylation and transcript levels of a number of genes in cord blood and placenta between children conceived using assisted reproductive technologies (ART) and children conceived in vivo.
In summary, this study supports that there are differences in DNA methylation at this locus between asthmatics and controls; and both SNPs and CpG sites are independently associated with ORMDL3 expression.
Our primary aim was therefore to determine whether there are differences in DNA methylation patterns in association with smoking between people of South Asian and European origin and to explore whether any differences observed could be explained by ethnic specific smoking behaviours.
Studies on tumour cells, lymphocytes and fibroblasts are rather contradictory and this may indicate that there are differences in the DNA conformation and sensitivity to radiation in cells of different origins.
At issue are differences in a single DNA letter between one person and another.
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